Brain abscess is caused by an infection of the brain. High-risk patients are those suffer from left to right shunt congenital heart diseases, sinus infection, or immune deficiency. Fatality rate from brain abscess is 20%. Two effective treatments are antibiotics and surgery. Treatment results depend on several factors including the patient’s condition and type of infection such as gram-negative bacteria or mold.
The study, aiming to assess influencing factors toward brain abscess treatment result, is a retrospective study of brain abscess patients during 1999-2013.
Based on the study of 114 patients, successful treatment must score 13-15 on the Glasgow Coma Scale (OR 14.64; 95% CI 2.70-79.34; p =0.02). On the other hand, failed treatment would include the case of mold infection (OR 40.81; 95% CI 3.57-466.49; p =0.003), intraventricular rupture of brain abscess (OR; 5.50; 95% CI 1.34-22.49; p =0.017). It was also found that the wider the distance between abscess and cerebral ventricles the significantly less likelihood the intraventricular rupture of the brain abscess would occur (OR 0.62; 95%CI 0.45-0.87; p=0.005). Every case of intraventricular rupture of the abscess occurred where the distance between abscess and cerebral ventricles was less than 7mms (p <0.000).
In conclusion, success rate of brain abscess treatment depends on the clinical condition of the patient, type of infection, and the risk of abscess rupture as well as prevention e.g. via surgery.