Assoc. Prof. Dr. Pharkphoom Panichayupakaranant
Faculty of Pharmaceutical Sciences, Prince of Songkla University
Awards: 1. Gold Medal from Brussels Innova Expo 2015, Belgium
2. Special Award “This is a Good Idea in 2015” from Taiwan Prominent Inventor Association, Taiwan
Mangosteen shell is an industrial byproduct that contains substance called alpha-mangostin that provides medicinal and pharmaceutical benefits. The substance extracted from magosteen shell includes xanthone and alpha-mangostin, are antibiotic, anti-inflammatory, antioxidant, and can heal wounds. Even though Dichloromethane is the found to be the best solvent to extract alpha-mangostin, it is unfortunately toxic and so unusable in pharmaceutical and cosmetic products.
A research effort to find an alternative “green solvent” is thus necessary for above reason. The research has identified Isopropyl myristate and Cetyl Alcohol as solvents through extracting method using a microwave which is also environmentally friendly. These two green solvents are comparable to Dichloromethane but safer and less expensive.
The aforementioned extracting process produces no less than 2.0% w/w of alpha-mangostin and can be safely incorporated into the medicine without having to be evaporated away which also means less production cost. The extract has been prepared into oral gel to treat mouth sore, with consistent concentration of 0.1-0.2% w/w of alpha-mangostin throughout the process.