Summary
Garcinia cowa is an edible plant commonly known in Thai as “Chamuang”. We have recently isolated a new polyprenylated benzophenone, namely “chamuangone” from G. cowa leaves. Chamuangone possessed a significant cytotoxic activity against lung adenocarcinoma (SBC3 and A549) and leukemia (K562, and K562/ADM) cells with IC50 values of 6.5, 7.5, 3.8, and 2.2 µM, respectively, as well as antibacterial activity against Streptococcus pyogenes (MIC 7.8 µg/mL), S. viridans and Helicobacter pylori (MICs 15.6 µg/mL), and Staphylococcus aureus, Bacillus subtilis and Enterococcus sp. (MICs 31.2 µg/mL) [1-2].